Detalhe da pesquisa
1.
Characterization of the cellular activity of PDE 4 inhibitors using two novel PDE 4 reporter cell lines.
Mol Pharm
; 10(10): 3697-705, 2013 Oct 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23987244
2.
Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders.
J Med Chem
; 66(17): 12203-12224, 2023 09 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37669040
3.
Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa.
J Thromb Haemost
; 20(6): 1400-1411, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35289054
4.
BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor.
J Med Chem
; 65(24): 16420-16431, 2022 12 22.
Artigo
Inglês
| MEDLINE | ID: mdl-36475653
5.
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun
; 12(1): 4375, 2021 07 16.
Artigo
Inglês
| MEDLINE | ID: mdl-34272366
6.
Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting.
ChemMedChem
; 15(21): 2010-2018, 2020 11 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32776472
7.
Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics.
J Med Chem
; 63(21): 12574-12594, 2020 11 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33108181
8.
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.
J Clin Invest
; 116(9): 2552-61, 2006 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-16955146
9.
The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents.
Neuropharmacology
; 55(5): 908-18, 2008 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-18674549
10.
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAYâ 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
ChemMedChem
; 10(7): 1163-73, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-26083237
11.
PDE-10A inhibitors as insulin secretagogues.
Bioorg Med Chem Lett
; 17(10): 2869-73, 2007 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17400452
12.
Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line.
Mol Pharmacol
; 68(6): 1775-81, 2005 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-16150925